Abstract
Gamma-turns are regular secondary structure elements, found with some frequency in small peptides, that have been implicated in the biologically active conformations of several systems. This report describes the design, synthesis and conformational analysis of a non-peptide γ-turn mimetic. Low energy conformations of the mimetic system exhibit good conformational agreement with an experimentally observed peptide γ-turn. The mimetics were incorporated into the nonapeptide bradykinin, for which a γ-turn, formed by residues Ser 6 to Phe 8, has been hypothesized to be a bioactive conformation. The results indicate that a bioactive conformation of bradykinin may include a reverse turn at this position.
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