Design, synthesis and characterization of novel 2-(2, 3-dichlorophenyl)-5-aryl-1,3,4-oxadiazole derivatives for their anti-tubercular activity against Mycobacterium tuberculosis

Abstract

Abstract Tuberculosis (TB) remains the leading cause of death from an infectious disease globally. The chemotherapy of TB is complicated by the protracted treatment regimens, development of multi-drug resistance coupled with drug-drug interactions with anti-retroviral and anti-diabetic agents. In search of finding a novel anti-TB compound, 2-(2, 3-dichlorophenyl)-5-aryl-1,3,4-oxadiazole derivatives have been synthesized by three-step chemical synthesis and purified by column chromatographic method. The synthesized final compounds 5a-l were characterized by 1H-NMR, 13C-NMR LC-MS, and elemental analysis. The antimycobacterial activity of the title compounds was evaluated against the Mycobacterium tuberculosis H37RvMa strain (ATCC 27294) by the broth micron-dilution method. The title compound 5f emerged as a promising anti-TB agent at 62.5 µg/mL.