Abstract
Abstract A novel polyazacyclophane hexa-amine (1) has been designed, synthesized and characterized by X-ray crystallography, 1H NMR and fluorescence spectroscopy. 1 has the structural shape and disposition of charges complementary to the major groove of B-DNA. Acid dissociation constants for the protonated 1 were pKa1(D) = 4.8 and pKa2(D) = 8.5. Equilibrium constants for the binding of 1 to ctDNA and T4 DNA were 1.2 × 105 and 1.8 × 106, respectively.
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