Abstract
In search of new antimicrobial agents with enhanced potency, we have designed and synthesized three series of hydrazones with 3‐methyl‐1‐phenyl‐1H‐thieno[2,3‐c]pyrazole‐5‐carbohydrazide. All the synthesized compounds have been screened for their in vitro antibacterial and antifungal activities by employing broth microdilution method. It is observed that compounds are more susceptible to Vibrio cholerae than other tested strains. In particular, compounds (3a), (3c), (5g), and (5 h) are highly potent against bacterial strain V. cholerae. The results suggest that hydrazones bearing two core pyrazole scaffolds would be potent antimicrobial agents.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have