Abstract
Natural products and natural product derived compounds are popular sources of new drugs and thus also play a pivotal role in the discovery and development of new antibiotics. The antibiotic fidaxomicin possesses promising antibacterial activity against several Gram-positive bacteria, though the poor bioavailability due to low water solubility, highly limits its clinical application. This thesis deals with our efforts to semisynthetically modify the macrocyclic antibiotic fidaxomicin (1) and presents our approaches starting from the isolation of this complex natural product from its natural source, the actinobacteria Actinoplanes deccanensis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
