Abstract
A range of amide derivatives of l-dopa were synthesized and investigated for their pharmacological activity and their ability to be converted to l-dopa using the unilaterally 6-hydroxydopamine (6-OHDA)-lesioned rat, as an experimental model of Parkinson’s disease. The diacetyl derivative of l-dopa amide ( 11b) was found to be more active than l-dopa after its oral administration and generated plasma levels of l-dopa in the therapeutic range for an antiparkinsonian effect in man.
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