Abstract
A new series of chalcone incorporated pyrimidine-pyrazine-oxazole (9a-j) compounds and their structures were confirmed by 1HNMR, 13CNMR and mass spectral data. All compounds assessed for their preliminary anticancer applications towards four human cancer cell lines like SiHa (human cervix cancer), A549 (human lung cancer), MCF-7 (human breast cancer) and Colo-205 (human colon cancer) by using of the MTT assay used the well-known chemotherapeutic agent etoposide as a positive control. According to the obtained data, most of the tested compounds displayed stronger activity compared with etoposides. Among the five compounds 9a, 9b, 9c, 9d and 9e possessed the most promising activities in all cell lines. Predominantly, two compounds 9a and 9b showed the highest anticancer activity.
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