Abstract
Recently, the inhibitory impact of enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) have emerged as a hopeful approach for pharmacological interference in various disorders such as epilepsy, Alzheimer's, Parkinson's disease and obesity. The biological and pharmacological properties of biguanidines and sulfonamides have made the compounds important. In this study, a series of biguanidine compounds (1–4) and their sulphonamide derivatives(1a-4a) were synthesized and their structures were elucidated by analytical and spectroscopic methods. The structure of compound 4 was determined by X-ray diffraction method. The synthesised compounds were showed for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory properties. The compounds were found to exhibit inhibitory properties for acetylcholinesterase and butyrylcholinesterase enzymes. amongst the tested compounds, it was determined that the sulfonamide compound, which contains benzamide in its structure, exhibited higher activity (IC50 138.47 µM) in AChE inhibition compared to other compounds.
Published Version
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