Abstract
A library of amide derivatives of oxazol-benzofuran-isoxazols ( 13a-j) have designed, synthesized and their structures were characterized by spectroscopic techniques. These compounds were investigated for in vitro anti-proliferative potential against human prostate cancer (PC3), human lung cancer (A549), human breast cancer (MCF-7) and human cervix cancer (SiHa) cancer cell lines by using of MTT asaay, and the etoposide used as standard reference. All compounds displayed remarkable anti-proliferative potential. Among them, compounds 13a, 13b, 13c and 13d showed most promising activities than etoposide. In which one of the compound 13c possessed superior activity. Further the structure-activity relationships (SARs) of these compounds were also examined.
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