Abstract
Abstract A general methods for synthesis of diverse precursors of phosphoinositides have been elaborated and applied towards synthesis of a variety of inositol phosphates, phospholipids, and their phosphorothioate, oxygen-labeled and stereoisomeric analogs. The obtained compounds have been used to study mechanism of phosphatidylinositol phospholipase C. The acquired mechanistic information was then applied for design and synthesis of inhibitors of this enzyme.
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