Abstract
we became interested in dihydrofuranyl phosphonate that would provide different constraint to the linker between phosphonate and the base. The dihydrofuran ring will serve as a rigid linker between purine/pyrimidine bases and phosphonyl groups of nucleotide inhibitors. A similar concept was introduced in a re-cent reports of dihydrofuryl nucleoside analogs that were shown to be anti-HCMV with resistance to enzymatic degradation,
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