Design, Synthesis and Antiviral Activity of 5-Hydroxymethyl-3-phosphonyl-4,5-dihydrofuran Analogs of Nucleotides

Abstract

we became interested in dihydrofuranyl phosphonate that would provide different constraint to the linker between phosphonate and the base. The dihydrofuran ring will serve as a rigid linker between purine/pyrimidine bases and phosphonyl groups of nucleotide inhibitors. A similar concept was introduced in a re-cent reports of dihydrofuryl nucleoside analogs that were shown to be anti-HCMV with resistance to enzymatic degradation,