Abstract
Objective: The principal objective of the study was to synthesize and evaluate the biological activities of a novel class of 5-benzylidene substituted rhodanine derivatives as antimicrobial agents.
 Methods: All the synthesized compounds (D1-D10) were screened for their antimicrobial activities using microdilution methods as per the reported procedure. All compounds were evaluated as potential antimicrobial agents against gram-positive bacteria: Bacillus cereus, Staphylococcus aureus, gram negative bacteria: Escherichia coli Pseudomonas aeruginosa and Klebsiella pneumoniae Fungal cultures used in the study were Aspergillus niger, Candida albicans, Candida parapsilosis, Candida tropicalis and Candida glabrata.
 Results: Compound D6 showed good antifungal activity in the MIC range 16μg/ml against Candida tropicalis and Compound D10 showed good antifungal activity in the MIC range 16μg/ml against Candida glabrata. Compounds D2 and D5 showed good antibacterial activity at 32μg/ml. all the other compounds showed moderate antibacterial activity.
 Conclusion: Based on the above results, it can be concluded that the compounds may lead to the development of more potent antimicrobial drug candidates in the near future.
Highlights
Synthesis and development of pharmaceutically active molecules have always been a primary objective of medicinal chemistry
We report in vitro activity of some very potent 3-(dialkylamino) alkyl substituted rhodanine derivatives
The reaction progress and purity of the synthesized compounds were monitored by analytical thin-layer chromatography (TLC) on pre-coated silica gel plates (Merck India Ltd)
Summary
Synthesis and development of pharmaceutically active molecules have always been a primary objective of medicinal chemistry. Treatment of infectious diseases is a challenging task for researchers and due to the increasing number of multidrug-resistant microbial pathogens, the discovery of new molecules to combat drug resistance is always a necessity [1,2,3,4,5,6]. The existing antimicrobial drugs for the treatment of infectious diseases are insufficient to protect us for the long term because of an increasing number of resistant strains. 1) by substituting various benzylidene derivatives at 5th position and the evaluation of their in vitro antimicrobial activity. We report in vitro activity of some very potent 3-(dialkylamino) alkyl substituted rhodanine derivatives
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