Abstract
A total of 18 derivatives S(1-18) of naphthoic acid linked Imidazo[2,1-b][1,3,4]thiadiazole were synthesized and tested for their anticancer potential at human cancer cell line A – 549. The interaction of the proposed derivatives with the colchicine binding domains of the receptor was also performed using Maestro 10.5 program (Schrodinger Inc. USA). Molecular docking study was performed for synthesized compounds displaying a significant inhibitory activity in order to validate their binding mode to active site. All the 18 inhibitors were docked into the active site of the receptor in two poses. The G-scores and binding energy for compound S4, S10, S12, S13 and S16 were observed to be comparable to the standard Colchicine. The compound S1, S5, S10, S12 and S16 exhibited prominent inhibition of cancer cell line.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
