Abstract
In this study a stepwise reaction has been designed for the synthesis of some new derivatives of Pyrazolinyl bromophenylthiazoles. The progress started by the benzylation of 2,4-dihydroxyacetophenone to give 1-[2,4-bis(4-chlorobenzyloxy)phenyl]ethanone (1) which was reacted with a number of benzaldehydes to produce a series of new α,β-unsaturated carbonyl compounds (2a-j). Followed by Michael addition with thiosemicarbazide affording new pyrazolines bearing thiocarbamoyl group(3a-j). A later derivatives were treated with 4-bromophenacyl-bromide yielding a series of a target pyrazolines having a thiazole linkages(4a-j).The final products were screened for their antimicrobial evaluations using micro broth dilution method against S.aureus as gram positive and E.Coli as gram negative.Spectroscopic techniques were utilized to elucidate the structures of the prepared compounds.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.