Design, Synthesis and Antibacterial Evaluation of Some New Pyrazolinyl Bromophenylthiazoles

Abstract

In this study a stepwise reaction has been designed for the synthesis of some new derivatives of Pyrazolinyl bromophenylthiazoles. The progress started by the benzylation of 2,4-dihydroxyacetophenone to give 1-[2,4-bis(4-chlorobenzyloxy)phenyl]ethanone (1) which was reacted with a number of benzaldehydes to produce a series of new α,β-unsaturated carbonyl compounds (2a-j). Followed by Michael addition with thiosemicarbazide affording new pyrazolines bearing thiocarbamoyl group(3a-j). A later derivatives were treated with 4-bromophenacyl-bromide yielding a series of a target pyrazolines having a thiazole linkages(4a-j).The final products were screened for their antimicrobial evaluations using micro broth dilution method against S.aureus as gram positive and E.Coli as gram negative.Spectroscopic techniques were utilized to elucidate the structures of the prepared compounds.