Abstract
The extracts of Inula britannica have anti-inflammatory, anti-bacterial, anti-hepatitic, and anti-tumor activities. Various sesquiterpene lactones with cytotoxic properties including 1- O-acetylbritannilactone ( 1) have been isolated from this Chinese medicinal plant. Eight derivatives of 1- O-acetylbritannilactone, (2- O-alkyloxime-3-phenyl)-propionyl-1- O-acetylbritannilactone esters were designed and synthesized. Four of these compounds were tested to show inhibitory activity on the growth of human leukemia HL-60 and cancer Bel-7402 cell lines.
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