Design, Syntheses, and SAR Studies of Carbocyclic Analogues of Sergliflozin as Potent Sodium-Dependent Glucose Cotransporter 2 Inhibitors

Abstract

Das niedermolekulare Kohlenhydratmimetikum Pseudosergliflozin wurde durch eine regio- und stereoselektive allylische Substitution synthetisiert. Es erwies sich als potenter und selektiver Inhibitor eines Transporterproteins (Natrium-abhängiger Glucose-Cotransporter 2, SGLT2), das für die Reabsorption von Glucose im menschlichen Körper zuständig ist, und könnte als Leitverbindung für die Entwicklung eines Diabetes-Wirkstoffs dienen. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.