Design, simulation and performance analysis bio-sensors for the detection of cholera and diarrhea using MEMS technology

Abstract

This paper presents two different types of micro channels namely one is cylindrical and the other is rectangular which are designed and simulated using FEM tool for the detection of cholera and diarrhea. Cholera is caused by vibrio cholera bacteria having dielectric constant 60 and Diarrhea is caused by E. coli bacteria having dielectric constant 40. Capacitance, flow velocity and flow rate are evaluated using FEM tool with and without bacteria cells. Along with the above analysis the performance analysis of the device also evaluated using FEM and MATLAB Tool. Sensitivity of cylindrical based micro channel is more than the rectangular micro channel because of low backward pressures in the cylindrical channel than the rectangular channel. The gap between the two electrodes are changed from 2.5, 2.4 and 2.3 μm in order to improve the performance of the device. The time taken by cylindrical channel for the detection of 150 cells of E. coli and V. cholera bacteria with a gap of 2.5 μm is (136, 205 s). The time taken by cylindrical channel for the detection of 150 cells of E. coli and V. cholera bacteria with a gap of 2.4 μm is (120, 180 s). The time taken by cylindrical channel for the detection of 150 cells of E. coli and V. cholera bacteria with a gap of 2.3 μm is (119, 178 s). The time taken by rectangular channel for the detection of 150 cells of E. coli and V. cholera bacteria with a gap of 2.5 μm is (345, 543 s). The time taken by rectangular channel for the detection of 150 cells of E. coli and V. cholera bacteria with a gap of 2.4 μm is (277, 518 s). The time taken by rectangular channel for the detection of 150 cells of E. coli and V. cholera bacteria with a gap of 2.3 μm is (165, 232 s). As the gap between the electrodes decreases the time taken for the detection also decreases. Accuracy also more for the cylindrical micro channel than the rectangular micro channel.