Abstract
The design requirements for a user-friendly computer-aided decision support system in laboratory medicine are considered. Central to the effectiveness of such a system is the incorporation of control system models of the relevant physiological dynamics. Interface requirements of the design include those between: clinical expert and knowledge base in order to establish an appropriate clinical rule-base; rule-base and control system models; these models and the clinical user; and clinical user and the IKBS. These design requirements for effective use of information derived from laboratory data in patient care are illustrated by reference to fluid/electrolyte, acid-base balance and thyroid disease.
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