Design, preparation and characterization of magnetic nanoparticles functionalized with chitosan/Schiff base and their use as a reusable nanocatalyst for the green synthesis of 1H-isochromenes under mild conditions.

Abstract

In this study, a Schiff base complex magnetic nanocatalyst was designed and prepared. The structure of the Fe3O4@CS-SB-CaMgFe2O4 nanocatalyst was characterized using FT-IR spectroscopy, XRD, VSM, FE-SEM, EDX, elemental mapping, BET, and TGA techniques. The synthesis of 1H-isochromene compounds has attracted the attention of chemists due to their biological and medicinal properties. The 1H-isochromene derivatives were synthesized in the presence of the Fe3O4@CS-SB-CaMgFe2O4 nanocatalyst with excellent efficiency and short reaction time as well as according to the rules of green chemistry. This reaction was carried out using Fe3O4@CS-SB-CaMgFe2O4 as a catalyst to develop a simple method with low activation energy at room temperature under optimal conditions. This catalyst provides a promising route for the synthesis of 1H-isochromene multiple times through its recyclability without significant loss of catalytic activity. This nanocatalyst possesses several advantages, including cost-effectiveness, facile separation, environmental friendliness, and recyclability, for the efficient production of 1H-isochromenes. The obtained compounds were further analyzed using spectroscopic techniques, such as melting point, FT-IR, 1H NMR, and 13C NMR analyses, to confirm their structures. The spectra of the synthesized compounds were recorded and analyzed, and a plausible mechanism for their synthesis was proposed. The characterization results and structural elucidation provide valuable insights into the preparation of these compounds.