Design, optimization, characterization of dapagliflozin loaded nlc using box-behnken design

Abstract

Dapagliflozin used to improve glycemic control, along with diet and exercise, in adults with type 2 diabetes is the model drug selected in the present research titled Design, Optimization, and Characterization of Dapagliflozin Loaded NLC Using Box-Behnken Design. Nano formulations are capable of providing site-specific delivery of anti-diabetic molecules to their specific site of action; this enhances the loco-regional concentration of the drug and reduces the systemic side-effects. Dapagliflozin loaded NLCs were prepared by emulsion–evaporation technique using Stearic acid as lipid and tweens & spans as surfactant. NLCs were characterized for particle size, zeta potential, entrapment efficiency and % drug release. The effects of composition of lipid materials and surfactant mixture and homogenization speed on the particle size, zeta potential, drug entrapment efficiency and in vitro drug release behavior were optimized. The optimized formulation OPT-DP-NLC has shown a particle size, entrapment efficiency and Zeta potential within projected limits, at 69.99 nm, 81.94% and -28.99 respectively.