Design, Optimization and Evaluation of Etoricoxib Castor Oil Emulgel for acute gout therapy

Abstract

Etoricoxibis is a non-steroidal anti-inflammatory drug which showed anti-inflammatory, analgestic and antipyretic activities. Etoricxib is indicates in the management of Osteoarthritis, Rheumatoid and Acute gout. The major drawback of topical dosage form is dissolution and diffusion of drug in the delivery of hydrophobic drugs, and permeation through stratum corneum is for hydrophilic drugs, thus, to be referred as emulgels. In emulgel formulations, oil-in-water and water-in-oil emulsions are commonly utilised as vehicles to deliver different hydrophilic and hydrophobic medications to the skin. They're also good in dissolving drugs and penetrating skin. Oil-in-water emulsions are mostly used as medication bases that may be washed away. The proposed research project intends to create an emulgel containing the analgesic drug Etoricoxib. The created emulgel containing etoricoxib medicines has a topical route that is more permeable, regulated, and localised. The analytical procedure of etoricoxib medicine was assessed using described UV spectrophotometric techniques in pH Phosphate buffer 6.8 and exhibited good linearity of data, as demonstrated by correlation coefficients greater than 0.998. For organoleptic characteristics, flow qualities, and partitioning, preformulation experiments were employed. All result of preformulation study was satisfactory and drug was examined visually for their feeling after application on skin, color intensity, pH determination, consistency and extrudability determination. The result concluded that ETEG4 was best formulation. This formulation ETEG4 was prepared emulgel Carbopol 940 (2g), PVP, castor oil base. The drug release profile and release kinetics are two important characteristics of the dosage forms, which play an important role for describing dissolution profile of dosage form. The dissolution data was obtained and ETEG4 showed supercase II transport mechanism.
 Keywords: Etorcoxib, Castor Oil, Emulgel, Osteoarthritis, Rheumatoid, Acute gout