Abstract
Peptic ulcer, it is the most common type of stomach disease, according to the American Gastroenterology Association. “We know that ulcers occur because there has been a disruption in the balance of factors that injure the digestive tract and those factors that protect it from injury,” The present investigation deal with the formulation, optimization and evaluation of sodium alginate based in situ gel of ranitidine hydrochloride (R-HCl) in ulcer treatment. The in-situ formulation are homogenous liquid when administration orally and become gel at the contact site. The evaluation of the formulation is dependent upon accurate results obtained by analytical method used during the study. Accurate results require the use of standard and a calibration procedure. Hence, standard plots of Ranitidine hydrochloride were prepared in (0.1N HCL, pH 1.2) solutions. Two, sodium alginate and calcium carbonate used as a polymer and cross-linking agent respectively in the formulation of in-situ gel. From the IR studies it may be concluded that the drug and carriers used undergo physical interaction there is no chemical change, and thus the gelling agent, cross-linking agent and other excipient is suitable for formulation of in-situ gel of ranitidine hydrochloride. Indicate that the formulation, DKF9 which was prepared by the Sodium alginate (2 gm) with Ranitidine Hydrochloride showed minimum drug release (sustained drug release) after 8 hrs. It can be concluded that the In-situ gel was beneficial for delivering the drug which needs sustained release to achieve the slow action.
 Keywords: In-situ gel, Peptic Ulcer, Ranitidine Hydrochloride (R-HCl), Sodium alginate.
Highlights
Indicate that the formulation, DKF9 which was prepared by the Sodium alginate (2 gm) with Ranitidine Hydrochloride showed minimum drug release after 8 hrs
The present investigation dealt with the formulation, optimization and evaluation of sodium alginate based in situ gel of ranitidine hydrochloride
This study reports that oral administration of aqueous solution containing sodium alginate result in formation of in situ gel
Summary
Ultraviolet spectroscopy analysis of drug was carried out for wavelength maxima and absorbance determination and calibration of standard curve of drug. This was done by forming various conc. Of solution (10-60 mcg/ml) (0.1 N HCl, pH 1.2) of drug and run the spectroscopy in the rage 200 to 400 nm to obtained the absorbance for their relative concentration was measured This was done by forming various conc. of solution (10-60 mcg/ml) (0.1 N HCl, pH 1.2) of drug and run the spectroscopy in the rage 200 to 400 nm to obtained the absorbance for their relative concentration was measured
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