Abstract
Despiteadvancements in wound management, chronic wounds still fail to heal in anappropriate time and manner. Hydrophobic drugs of interest to the pharmaceuticalindustry exist that are suggested to reduce inflammation and aid in the woundhealing process; however, delivering these drugs poses a challenge both interms of ease of formulation processing and drug release characteristics whenapplied in vivo. Naturally occurring, biocompatible, and bioactive excipients,such as hydroxyethylcellulose (HEC) andcitric acid (CA) are hydrophilic and widely used in wound management anddelivery of soluble drugs. However, hydrophobic drugs are not compatible inthis environment without the addition of molecules, such as β-cyclodextrin(βCD), which acts as a drug carrier and allows drug delivery. This study investigatedthe use of CA in formulation development to achieve crosslinking of HEC and βCDto allow the incorporation of poorly soluble model drugs. The prepared filmshave been characterized for their functional physico-chemical properties relevantfor wound healing applications.
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