Abstract
This current study was conducted to investigate the optimal fabrication variable that would give desirable properties in designing hydrogel wound dressings. This new PVA/chitosan hydrogel loaded with Chromolaena odorata were fabricated using solvent-casting method. Variables including PVA concentration (3, 5, 7 and 10% w/v), chitosan concentration (1, 2, 3, 4 and 5% w/v) and PVA/Chitosan ratio (10:90, 30:70, 50:50, 70:30 and 90:10) were investigated and elucidated. Hydrogel properties including tensile strength, swelling capacity, erosion rate and porosity were measured and effects of the fabrication variables towards these properties were elucidated. In conclusion, desirable PVA/Chitosan hydrogel loaded with Chromolaena odorata extract as wound dressing was favorly designed. The optimal range for PVA concentration, chitosan concentration and PVA/Chitosan ratio were 5% to 7%, 2% to 3% and 50:50 to 70:30 respectively.
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