Abstract
A gum isolated from Pistacia lentiscus of Pistacia genus was used as a release modifier in the preparation of diclofenac sodium spheroids, using the extrusion–spheronization technique. Spheroids prepared were formulated using diclofenac sodium, mastic gum (2.5–15%) and microcrystalline cellulose. Here, variables were studied and spheroids were characterized for average size, surface morphology, friability, bulk density and flow properties. In vitro drug release profile indicated an increase in drug release retardation with increasing mastic gum concentration. The formulated spheroids were stable with respect to their physicochemical characters and drug content over a period of 60 days at different temperatures and relative humidity. The objective of this study was to evaluate the influence of roll compaction and tableting on release of diclofenac sodium. Tablets prepared at different compression force played a key role in the dissolution of drug. Finally, the sustained release properties of spheroids were also maintained after compression.
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