Design of Novel Oligomeric Mixed Ligand Complexes: Preparation, Biological Applications and the First Example of Their Nanosized Scale.

Rawda M Okasha,Arshi Naqvi,Eman H Ismail,Najla E Al-Shaikh,Faizah S Aljohani

doi:10.3390/ijms20030743

Rawda M Okasha, Arshi Naqvi + Show 3 more

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https://doi.org/10.3390/ijms20030743

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Abstract

A successful oligomerization of ternary metal complexes, cobalt (II), nickel (II), copper (II), zinc (II), chromium (III) and ferric sulfate (III) with nitrilotriacetic acid (NTA) as a primary ligand and glutamic acid as a secondary ligand, has been demonstrated. The formation of oligomers arose from the presence of the sulfate moiety, which operates as a bridged bidentate ligand that coordinates with other metal moieties. The novel oligomers exhibited octahedral structures, which bonded together through the sulfate moiety. In silico predictions were conducted to gauge the bioactivity, physico-chemical and pharmacokinetic properties. The biological activities of these oligomers as well as their tumor inhibitory behavior have been explored. This work also presents a facile and novel method of preparing these materials in nanosize, using Cetyltrimethylammonium bromide (CTAB) and polyvinyl alcohol (PVA) as capping ligands. The size and shape of the nanomaterials have been confirmed using the transmission electron microscope (TEM) and the scanning electron microscope (SEM).

Highlights

Coordination compounds and macromolecules are an eminent class of material that are encountered daily [1,2,3,4,5,6,7]
We introduce a prosperous attempt to synthesize the first example of ternary metal complexes, containing oligomers in nanoscale
The octahedral structure of each monomeric unit is formed via two oxygen and one nitrogen atoms of the HNTA−2 moiety combined with the carboxylic groups of the glutamic acid and the two halves of the sulfate groups, which bind to the metal ions as bridged bidentate ligand, forming the oligomeric materials [49]

Summary

Introduction

Coordination compounds and macromolecules are an eminent class of material that are encountered daily [1,2,3,4,5,6,7]. The metal-organic coordination macromolecules exhibit remarkable stability in comparison to their discrete complexes due to their macrocycle or chelate effect. The synthesis of these coordination oligomers and polymers was accomplished via several successful strategies, such as the metalloligand strategy, pillar-layered and supramolecular building blocks and layers. The study of the structure of their model ternary complexes provides information on how the biological systems attain their specificity and stability [27]. From this perspective, two complexing agents have been selected to synthesize a new family of coordination oligomers, containing mixed ligand complexes. This coordination behavior alters metals’ bioavailability, mobility and persistence in the environment [28]

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