Abstract
Structural requirements for melanin biosynthesis inhibition were analysed by comparing known melanin biosynthesis inhibitors (MBIs) and an intermediate of melanin biosynthesis (1,3,8-trihydroxynaphthalene (1,3,8-THN)), on the assumption that the enzymatic inhibition by MBIs occurs competitively with the biosynthetic intermediate. On this basis, new chemicals in the form of phthalazine derivatives were designed. In biological tests, the synthesised phthalazine derivatives showed high activity against rice blast, caused by Pyricularia oryzae Cav. These compounds also inhibited the melanisation of this fungus at a low concentration, which suggested that they are similar to other MBIs in their mode of action.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
