Abstract
Developing intelligent nanomedicines for cancer diagnosis and treatment (theranostics) is pivotal for improving treatment outcomes. In this study, we synthesized and evaluated dual-mode MRI contrast agents utilizing superparamagnetic iron oxide nanoparticles (SPIONs) as the core and samarium ions as the coating. Samarium ions were grafted onto the polymeric coating layer of the nanoparticles via electrostatic deposition. Characterization of the Cis/Fe3O4/PEG-co-PMMA/SmO2 core/shell structures involved size, morphology, drug loading, encapsulation efficiency, and their potential as T1-T2 dual-model contrast agents. Longitudinal relaxivity (r1) and transverse relaxivity (r2) were estimated using NMR relaxation times. In vivo investigations assessed the effectiveness of Cisplatin, particularly in human breast cancer (MCF-7) cells, using wound healing assays and molecular analysis. Remarkably, the Cis/Fe3O4/PEG-co-PMMA/SmO2 formulation exhibited enhanced cytotoxicity against MCF-7 cells compared to Cisplatin alone, indicating its promising role as an inhibitory agent against breast cancer cell proliferation.
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