Abstract
Chitosan/zein films were developed for controlled release of ellagic acid using a central composite design to evaluate the effect of the polymers concentration on the films’ characteristics and its application as a wound bandaging platform. The films’ characteristics were predicted with quadratic models. Responses were found to depend on the composition of the film, with both polymers exerting a significant influence on the resulting thickness and contact angle (p < 0.05). Zein presented a significant influence on the release of ellagic acid. Furthermore, the obtained films presented suitable thickness, high sorption and controlled release pattern. Most films presented inhibitory activity against Staphylococcus aureus and Pseudomonas aeruginosa in vitro, supporting their use as a bandaging platform with antimicrobial features. These results show that the polymeric films prepared could become a therapeutic option to prevent/treat cutaneous-mucous infections and to aid on the skin rehabilitation.
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