Abstract
In the present work, it was planned to prepare sub dermal implants for the treatment post operative surgical care in breast cancer patients. Meloxicam the anti-inflammatory agent was chosen as a model drug due to its wide spectrum of activity, low toxicity and high efficiency against inflammation. Bio degradable Gelatin based Implants comprised plasticizer, glycerin was formulated. The implants were evaluated for drug content uniformity, thickness, weight variation, IR, microbial degradation studies. Invitro release of implants was studied in phosphate buffer pH 7.4 and stability studies were done at ambient temperatures for 3 months. In-vivo studies in rabbits were carried out for polymer- tissue compatibility at sub dermal region. The prepared Meloxicam sub dermal implants were found to contain uniform drug content, weight, thickness and invitro release of Meloxicam sub dermal implants which are treated with formaldehyde for 12 hours was found to be sustaining release of drug for a period of 6 days. In-vivo studies in rabbits for polymer tissue compatibility, in animals showed encouraging results depicting no changes in tissue configuration histopathologically and compatible with the surrounding tissue of sub dermal region.
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