Abstract
Why are diradicals used as hydrogen abstraction agents in the enediyne antitumor antibiotics, and what would happen if a “nonnatural” diradical were to be used? The very slow abstraction rates by arene diradicals suggest an answer to the question of the functional significance of diradicals versus monoradical abstraction agents in the natural products, and furthermore, suggest potential strategies for the rational modification of DNA‐cleaving agents by alteration of the diradical “warhead”.
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