Abstract
Cross-linked starch nanocapsules (NCs) were synthesized by interfacial polymerization carried out using the inverse mini-emulsion technique. 2,4-toluene diisocyanate (TDI) was used as the cross-linker. The influence of TDI concentrations on the polymeric shell, particle size, and encapsulation efficiency of a hydrophilic dye, sulforhodamine 101 (SR 101), was investigated by Fourier transform infrared (FT-IR) spectroscopy, dynamic light scattering (DLS), and fluorescence measurements, respectively. The final NC morphology was confirmed by scanning electron microscopy. The leakage of SR 101 through the shell of NCs was monitored at 37 °C for seven days, and afterwards the NCs were redispersed in water. Depending on cross-linker content, permeable and impermeable NCs shell could be designed. Enzyme-triggered release of SR 101 through impermeable NC shells was investigated using UV spectroscopy with different α-amylase concentrations. Impermeable NCs shell were able to release their cargo upon addition of amylase, being suitable for a drug delivery system of hydrophilic compounds.
Highlights
The development of new strategies for the delivery of hydrophilic drugs is emerging as an important research field [1,2,3,4,5,6] due to several facts: water-soluble drugs are often degradable in the body, poor cellular penetration of macromolecules, toxicity of small molecules, and unsuitable biodistribution [1]
Some NCs precipitated during permeability of NCs was evaluated and impermeable shell cross-linked starch NCs were designed for enzyme-triggered release of hydrophilic compounds
Effect of starch amount on (a) average particle size and (b) shell composition of cross‐linked starch NCs prepared with 120 mg of toluene diisocyanate (TDI) and 10 wt% of PGPR related to the dispersed phase
Summary
The development of new strategies for the delivery of hydrophilic drugs is emerging as an important research field [1,2,3,4,5,6] due to several facts: water-soluble drugs are often degradable in the body, poor cellular penetration of macromolecules, toxicity of small molecules, and unsuitable biodistribution [1]. These limitations can be overcome by the use of nanocarriers that offer protection against degradation or oxidation until the drugs reach the targeted tissues. Starch-based nanoparticles have been obtained using modified [17] and cross-linked starch [18]
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