Abstract
Automated anesthetic drug propofol infusion system needs to be optimizing to avoid adverse post-reactions during surgery. In this paper, fractional-order control design based on commande robuste d’ordre non entier (CRONE) concept is proposed for automatic propofol infusion. This paper proposes a robust model-based fractional-order controller combined smith predictor design for automatic propofol administration. The fractional order used cascade combination of proportional–integral–derivative (PID) and fractional-order filter (FOF). The proposed control scheme improved the controller performance with respect to regulatory and servo control. The conventional fractional-order PID controller demands five tuning parameters. But the proposed design required only two parameters. Simulation results are obtained for different BIS set points and surgical stimulation during surgery. The pharmacological data of 20 patients’ has been used in the simulation to estimate body dynamics, and results are also compared with two different controllers.
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