Abstract
Twisted rod-like structured chiral mesoporous silicas (CMSs) have been firstly synthesized with the novel template systems from ursodeoxycholic acid (UDCA)/chenodeoxycholic acid (CDCA) and CTAB. CMSs were characterized by various instrumental techniques, demonstrating highly ordered hexagonal mesoscopic phase and twisted rod-like morphology. Induced circular dichroism (ICD) indicated the preferential optical activity of the CMSs with involving phenol as a probe. Besides, CMSs exhibited chiral-selective delivery of achiral drug indometacin (IMC) and nimesulide (NMS) in simulated chiral environment. We believe that the novel synthesized CMSs were expected to be desirable carriers for drug delivery in the pharmaceutical field to extend the applications of inorganic nanomaterials.
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