Abstract
To moderate fast neutrons produced by accelerator to appropriate therapeutic energies for boron neutron capture therapy (BNCT), beam shaping assembly (BSA) is required definitely. In this work, based on a model of 2.5 MeV/30 mA proton accelerator, the Monte Carlo simulation software MCNPX was employed to design multi-terminal BSAs. All parameters for both the thermal and epithermal neutron beams at the exit ports of the designed BSAs meet the treatment recommendation values proposed by the International Atomic Energy Agency (IAEA). The clinical parameters of the thermal and epithermal neutron beams were also calculated for clinical indication consideration.
Highlights
Boron neutron capture therapy (BNCT) is a novel modality of radiation cancer therapy
Boron compounds are administered to tumor cells, the tumor is irradiated with neutrons, inducing the 10B (n, α)7Li nuclear reaction: 10B + nth →11 B →4 He (1.78 MeV) +7 Li (1.01 MeV) (6.3%) 10B + nth →11 B →4 He (1.47 MeV) +7 Li (0.84 MeV) + γ (0.48 MeV) (93.7%) [1]
The γ ray component is lower than 316L Stainless steel, Al2O3 and Teflon, so BeO was selected as the reflector material. It shows that when the radius is > 45 cm, the reflector radius has no significant influence on the neutron beam parameters
Summary
Boron neutron capture therapy (BNCT) is a novel modality of radiation cancer therapy. Boron compounds are administered to tumor cells, the tumor is irradiated with neutrons, inducing the 10B (n, α)7Li nuclear reaction: 10B + nth →11 B →4 He (1.78 MeV) +7 Li (1.01 MeV) (6.3%) 10B + nth →11 B →4 He (1.47 MeV) +7 Li (0.84 MeV) + γ (0.48 MeV) (93.7%) [1]. Both α particles and 7Li nuclei deposit their energies along their very short paths, which are comparable to the size of cells. Clinical trials of BNCT were conducted in the United States, Sweden, Finland, the Czech Republic, Argentina, the European Union (centered on Finland) and Japan
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