Design of backstepping LQG controller for blood glucose regulation in type I diabetes patient

Abstract

The mechanisation of the insulin infusion regulation through the artificial pancreas (AP) is needed to design with an objective to control the blood glucose (BG) level in type 1 diabetes mellitus (T1DM) patients. However, to make it applicable in real time, major components needed are availability of proper sensor augmented pumps, glucose monitoring systems, and control techniques. Recent times many researchers suggest robust control techniques for designing a robust controller for computing the required insulin dose for a highly nonlinear human metabolism system. This paper proposes a simulation model of glucose metabolism process and design of a backstepping linear quadratic Gaussian controller (BLQGC) to control the BG level in TIDM patients. The simulations are carried out through MATLAB/SIMULINK environment and the results indicate comparatively better control ability of the proposed algorithm to control the BG concentration within the range of normoglycaemia in terms of accuracy, stability, quick damping and robustness.