Abstract
A novel and simple organocatalyst derived from proline was designed, synthesized and tested for its catalytic potential in a direct asymmetric aldol reaction between 4-nitrobenzaldehyde and cychlohexanone in aqueous media. The relatively inexpensive and safe solvent, water stabilized the transition state, and increased reactivity and selectivity of catalyst. The diastereo- and enantio-selective products of the reaction were obtained in excellent yields.
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