Abstract
In this paper, we formulate a method to create a potential drug delivery vehicle and scaffold architecture of coaxial electrospun fibers. Having the capability to introduce porosity either in core or sheath of the fiber using supercritical CO2 as a foaming agent is utilized. Polycaprolactone (PCL) and Poly butylene adipate-co-terephthalate (PBAT) were used because of their biodegradable and biocompatible nature. Physical morphology of the porous coaxial fibers was studied using Scanning Electron Microscopy (SEM), Image J software was used to quantify the pore size and fiber diameter. Dynamic Mechanical Analysis (DMA) and Tensile Testing of the three-dimensional fibrous mesh was done to determine the mechanical properties of the porous structure. Differential Scanning Calorimeter (DSC) was used to study the thermal characteristics of the mesh.
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