Abstract
The goal of oncological surgery is to completely remove the tumor. Tumors are often difficult to observe with the naked eye because of the presence of numerous blood vessels and the fact the colors of the tumor and blood vessels are similar. Therefore, a fluorescent contrast medium using a surgical microscope is used to observe the removal status of the tumor. To observe the tumor removal status using a fluorescent contrast agent, fluorescence is expressed in the tumor by irradiating with an external light source, and the expressed tumor can be confirmed through a surgical microscope. However, not only fluorescence-expressed tumors are observed under a surgical microscope, but images from an external light source are also mixed and observed. Therefore, since the surgical microscope is connected to a filter, the quality of the diagnostic image is not uniform, and it is difficult to achieve a clear observation. As a result, an asymmetric image quality phenomenon occurs in the diagnostic images. In this paper, a filter with high clarity that provides a symmetrical observation of diagnostic images is developed and manufactured.
Highlights
The purpose of surgery is to completely remove malignant tumors with high dislocation rate and strong invasiveness [1]
Since the main purpose of this study is to investigate the effects of a long-pass filter on a fluorescence image, this paper is premised on the assumption that the peak fluorescence emission intensity is reached at the concentration of 0.0102 mM
The effect of long-pass filter on fluorescence image observation was investigated because the current surgical fluorescence microscope cannot produce clear images due to asymmetric light distribution
Summary
The purpose of surgery is to completely remove malignant tumors with high dislocation rate and strong invasiveness [1]. Because the color of the tumor and blood vessels are similar, it is often difficult to visually observe the tumor removal status. A yellow-dye (530–560 nm) fluorescence contrast medium is injected into the body to distinguish blood vessels from tumors, and the surgical area is exposed to an external light source (405 nm) to induce fluorescence emission from the tumor [2]. The wavelength and color images that fluoresce in the tumor can be observed on an external monitor through the camera of a surgical microscope [3]. Since the surgical microscope captures the fluorescence color image of the tumor and the color image of the external light source together through the camera, the external monitor observes the color image of the external light source and the fluorescence color image of the tumor mixed
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