Abstract
Elementary osmotic pumps releasing solutions of active materials at a controlled rate have increased in popularity during the last two decades. In this study, the effect of the delivery orifices and the concentration of osmotic agents on the rate of release of the active material was investigated. For this purpose, ibuprofen tablets were prepared and sodium chloride and polyethylene glycol 6000 were used as osmotic agents. The tablets were coated with a mixture of cellulose acetate and polyethylene glycol 400 by the use of a modified fluidized bed apparatus. Delivery orifices on the coated tablets are produced using a microdrill. The tablets were tested for dissolution rate using the USP paddle method. Finally, it was observed that the release rate of ibuprofen was influenced by the concentration of osmotic agents sodium chloride and polyethylene glycol 6000.
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