Abstract
A novel series of 1,2,3-triazolyl-pyrazole-chalcone derivatives were synthesized by using different chemical reaction such as Vilsmeier-Haack reaction, Click reaction and Claisen-Schmidt reaction. Optimization of the Click reaction conditions resulted that the triazoles gave higher yield with short reaction time by using CuI and TEA in water medium. The compounds were screened for their in vitro antimicrobial and antioxidant activities, among them the compounds 8f and 8i showed better antimicrobial activity and the compounds 8g were showed good antioxidant activity. The molecular docking studies suggested that the compounds 8f and 8i have best potent dock score then compared with Amoxicillin. The compound structures were established on the basis of various analytical data including 1 H & 13 C-NMR and mass spectrometry.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
