Design, Installation and Commissioning Of Clean Room and Hvac Facility for Stem Cell Technologies and Regenerative Medicine

Abstract

Today, many manufacturing process requires that spaces to be designed to control particulate and microbial contamination while maintaining clean room facility with reasonable installation and operating costs. Clean room facilities are typically used in manufacturing, packaging and research facilities associated with these industries: Semiconductor, Pharmaceutical, Hospitals, Aerospace and Miscellaneous applications. This project deals with Design, Installation and Commissioning of Clean room and HVAC facility for Stem cell technologies and Regenerative Medicine. In this thesis, the system design thermal loads , filtration level and cleanness, pressures produced in the constructed building by varying normal brick wall ,brick wall with attached panels are calculated..Clean rooms are designed as per ISO14644-4 guidelines to maintain proper air flow in order to used proper cleanness. The HVAC facility shall be achieved by using the equipments like Air cooled condensing unit, Air handling units and etc..As a First step towards the project, the system design load calculations will be done. Air Quantity calculation, Supply/Return air Diffusers, Return Air Risers and Terminal filters selection, Temperature, RH, Lighting and Fan requirements are as per attached design data sheets. The classes of cleanliness, filtration and other requirements are to be as per the room list, layout drawings .The minimum fresh air quantities shall be as per the basis of design above while the exhaust air quantities shall be as based on the quantities of the leakages and pressures to be maintained in the rooms and Also the leakage rates considered through the doors to be through the doors to be through a normal single leaf door or double leaf door for the suggested pressure differentials to be suitably considered.