Abstract
The aim of the present study was to improve dissolution of poorly water-soluble Celecoxib by solid dispersion technique using water soluble carriers. Solid dispersions of Celecoxib were prepared with different polymers or carriers such as Hydroxy Propyl Beta Cyclodextrin, polyvinylpyrrolidone (PVP K30) and Urea. Solid dispersions were formulated in drug polymer ratio 1:2.5, 1:5, 1:7.5 and 1:10 using solvent evaporation method. The prepared formulae were assayed for drug content, production yield and micromeritics properties. Dissolution profiles were done in water containing 1% sodium lauryl sulphate and the in-vitro release was ranked according to the % drug released after 60 and 120 minutes. The results indicated that all of the formulated solid dispersions displayed better dissolution profiles as compared to the pure drug. Formula containing drug to HP-β-CD (1:10) was ranked first and gave the best results out of the 12 solid dispersion formulae prepared.
Highlights
The term ‘solid dispersion’ has been utilized to describe a family of dosage forms whereby the drug is dispersed in a biologically inert matrix, usually with a view to enhancing oral bioavailability
Celecoxib was formulated as solid dispersions using the solvent-evaporation technique
CXB-U(1:10) CXB-HP- β -CD(1:2.5) CXB-HP- β -CD(1:5) CXB-HP- β -CD(1:7.5) CXB-HP- β -CD(1:10). This present study showed that when Celecoxib was dispersed in a suitable watersoluble carrier such as HP-β-CD, PVPK30 and Urea, its dissolution was enhanced compared with pure drug
Summary
The term ‘solid dispersion’ has been utilized to describe a family of dosage forms whereby the drug is dispersed in a biologically inert matrix, usually with a view to enhancing oral bioavailability. Another definition was ‘molecular mixtures of poorly water soluble drugs in hydrophilic carriers. It has been shown that the dissolution profile can be improved if the carrier has surface activity or self-emulsifying properties, third generation solid dispersions appeared. These contain a surfactant carrier, or a mixture of amorphous polymers and surfactants as carriers
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