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Abstract
Background: Developing a simple HPLC method requires an expansive array of literary evidence and experimental routines to perceive the nature of a drug and eventually determine the specific mobile phase and column to be used for attaining better results. Objective: The study aimed to develop and optimize a new, simplified, robust, and sensitive method for the determination of cilostazol in tablets by high-performance liquid chromatography using a Box Behnken design. Methods: The chromatographic separation was carried out on an ODS C18 (4.6 X 250mm and 5μm) column with acetonitrile and methanol (25:75 % v/v) at an effluent flow rate of 1 mL/min and detected at 257 nm. Result: The method was found to be linear in the concentration range of 10-50 μg/mL, and the correlation coefficient was found to be 0.988, and the recovery of cilostazol was 98.16%. The optimized method validated as per ICH Q2A guidelines was found to be accurate, precise, robust, and stable. Conclusion: This research thus throws light on the implementation of statistical multivariate analysis techniques used for drug analysis.
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