Abstract
ABSTRACT The present research was aimed at synthesising and characterising curcumin-loaded zinc oxide nanoparticle-decorated mesoporous silica as a tissue adhesive (Liquid Stitches). The mesoporous silica nanoparticles facilitate adhesion to tissues through the nanobridging effect. The mesoporous silica was synthesised using a sol–gel methodology, and the drug was incorporated using the wetness impregnation method. The platform that was prepared was characterised using infrared spectroscopy, TEM, DSC, XRD, particle size analysis, BET analysis, a tissue model adhesion test, an antimicrobial assay and a wound model in Sprague Dawley rats. The average particle size was found to be 72.4 nm, while the surface area was found to be 654 m2/g. The tissue model adhesion graphs showed significantly different values for the peak load, work done and deformation at peak load, which reflects a difference between the glue strengths of the mesoporous silica nanoparticles and the Cur-ZnO-MSN and the carrier medium (water). The animal study provided a proof of concept by glueing wounds in less than 1 minute and healing the wound within 5 days.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
