Abstract
The aim of the present research study was to develop and evaluate the topical microemulsion for antifungal activity by using Terbinafine HCl as antifungal agent. The pseudo ternary phase diagram was method adopted to optimize the amount of oil (Cinnamon oil) (X (1)), Smix (mixture of Span 80 & Isopropyl alcohol (as surfactant & co-surfactant respectively)) (X (2)) and Water (X (3)) in the microemulsion formulation. The microemulsion which containing drug, cinnamon (67.30 % w/w), 28.84 % w/w Smix (Span 80 & Isopropyl alcohol) and water (3.84 % w/w) was selected as optimized formulation. With viscosity 18,600 m.Pa.s, refractive index 1.601±0.002 and TEM image shown that micro-droplets were almost spherical in shape. The in-vitro skin permeation and retention studies were also performed using Franz diffusion cell with membrane filter. In-vitro skin permeation was lowest and retention was highest (9.3±3.10; 90.60±3.09 respectively) after 6 hours study. The optimized or selected formulation showed better antifungal activity against Candida albicans than the commercial cream. It was concluded that drug loaded microemulsion could be a promising formulation for effective treatment of topical fungal infection.
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