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Abstract
Medication are vital for life many medications, as tablets, suspensions, and capsules, are taken by the oral route, which has a systematic effect as it reaches different body sections via the bloodstream. Suspension is the best formulation for the treatment of various diseases such as depression for better patient compliance. Many types of drugs are there on the market for the treatment of depression-like fluoxetine, atypical antipsychotic, norepinephrine, monoamine oxidase inhibitors, a potent inhibitor of cytochrome P-450 isoenzymes, and serotonin reuptake inhibitors are also used. There are some drawbacks such as dry mouth, constipation, sedation, insomnia, tachycardia, sweating, less patient compliance, etc. Duloxetine HCl is a BCS class 2 drug that is selective serotonin and norepinephrine inhibitor. It helps to stop the pain signals in the brain by maintaining the normal levels of serotonin and norepinephrine in the brain. To overcome the drawback of patient compliance, the present study is to develop and optimize polymer-coated delayed-release suspension of Duloxetine HCl and opens a new window for researchers to develop a suspension for the treatment of depression.
Published Version
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