Abstract
Design, Development and Characterization of Valsartan Microsponges by Quasi Emulsion Technique and the Impact of Stirring Rate on Microsponge Formation
Highlights
The results showed that, generally an increase in the ratio of the drug: polymer and stirring rate resulted the cumulative percentage drug release up to 8 hrs for M7, M8, M9 were 72%, 89% and 94% respectively and entrapment efficiency values of 33.8 - 84.5 respectively
The particle size of valsartan microsponge formulation were given in Table no 2.The formulations with ethyl cellulose F1-F9 shows the average particle sizes of 83.2,79.3, 65.2, 61.6, 54.8, 45.3, 48.5, 39.2 and 29.6 respectively
The thought behind developing polymeric microsponge delivery system was to deliver active ingredient in a continual manner for extensive time period to reduce application frequency, hypersensitive reactions and to improve bioavailability, safety than marketed conventional formulation and precisely control the release rates or target drugs to a specific body site have a vast impact on the health care system
Summary
They are highly cross linked, porous polymeric microparticles which contain countless interconnected voids within a non-collapsible structure (D’souza et al, 2014) They are usually between 20 and 200 microns in diameter that acquire the flexibility to entrap a wide variety of active ingredients such as emollients, fragrances, sunscreens, essential oils, anti-infective, antifungal and antiinflammatory agents etc., that are mostly used for prolonged topical administration (Jain et al, 2011). Their use is being investigated for oral drug delivery. In our present work Valsartan microsponges were prepared by quasi emulsion solvent diffusion technique with different stirring rates
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