Design, Development and Characterization of Ropinirole Mouth Dissolving Film by using Spin Coating Technique

Abstract

The aim of the research was to develop a ropinirole mouth-dissolving film employing solvent casting and spin coating methods with sesbenia gum acting as a film-forming agent. Parkinson’s disease is treated with ropinirole. Sesbenia gum was designed as a film-forming ingredient in the 25 to 600 mg concentration range for solvent casting and 50 to 250 mg for spin coating. For both procedures, the concentration of the plasticizer propylene glycol was optimized between (0.3 and 1.0 mL). Film-forming agent and plasticizer effects at various concentrations were examined. For the solvent casting and spin coating processes, the plasticizer concentration was 0.3 mL for each, while the optimal film-forming agent concentrations were 50 and 150 mg, respectively. Ropinirole MDFs were made employing an enhanced concentration and more excipients. In comparison to the solvent casting approach, the spin coating process produced films with better surface morphology, a 24 seconds shorter disintegration time, good tensile strength of 3.2 (N/mm2), a thinner thickness of 0.2 mm, and a maximum drug content of 93.14%. Sesbenia gum has been discovered to have greater potential for the spin-coating method of developing a ropinirole mouth-dissolving film.