Design Development and Characterization of Nicardipine Solid Lipid Nano-Particulars

Abstract

The present work was designed and characterized nicardipine solid lipid nano-particulars and formulated into capsule. The formulation was evaluated and stability also as per the specified limits. The nanoparticles were prepared by solid hydrophilic adsorbents. The obtained ratio of 1:1:1:2 of drugs, soy PC, DMPC, and labrasol shows the highest dissolved in water. The liquid form was converted into a solid product using an adsorbent like anhydrous lactose and aerosil 200. The above results indicated aerosil 200 containing which helped in enhanced dissolve state in water. The results indicated the formulation trial-6 %drug content -100.2, entrapment efficiency 84.13 ± 1.64, zeta potential measurement 0.789 ± 0.32, Drug release rate at 3rd hour 81.6% and relative bioavailability of optimized nanoparticle formulation (CNF-6) was significantly increased. As a result, the produced lipid-based formulation shown potential as a method for improving the transfer of lipophilic chemicals that are weakly water-soluble to the aqueous phase, hence improving oral bioavailability